Division and Department

Department of Neurosurgery


Hiroaki SHIMIZU, M.D. & Ph.D.

A Greeting from the Professor

The Department of Neurosurgery at Akita University offers the most up-to-date evaluation and treatments for all neurosurgical disorders, including cerebrovascular diseases, brain tumors, head trauma, and other related neurosurgical problems.

In cerebrovascular surgery, we employ both endovascular therapy and open surgery depending on the disease and patient’s condition. In brain tumor surgery, patients are sent from all over the Akita prefecture and we perform multidisciplinary treatments including surgery, chemotherapy and stereotactic radiosurgery in collaboration with other departments such as radiology, oncology and pediatrics. In functional neurosurgery, we perform surgery for trigeminal neuralgia and facial spasm. Neurosurgical operating rooms are equipped with image-guided stereotaxis, neuro-endoscopy, brain mapping, and various neurophysiological monitoring. These facilities, as well as an endovascular suite and a stereotactic radiosurgery system, help us provide safe and successful treatment of some of the most complex intracranial aneurysms, arteriovenous malformations, brain tumors, cerebral ischemic diseases and others.

Our training programs are designed to promote understanding of neurosurgery (including microneurosurgical techniques and skills) and to inspire a multidisciplinary approach to achieve the best clinical results and a scientific spirit of inquiry. Our research programs have also recently expanded, particularly in the areas of ischemic brain injury and brain tumor molecular biology in collaboration with basic research departments in Akita University as well as in Japan and overseas. Our goal is to provide the excellent care to patients with neurosurgical disorders, and this is accomplished through the advancement of scientific knowledge and technical expertise.

Sincerely,

Hiroaki SHIMIZU, MD
Professor and Chairman, Department of Neurosurgery

Staff

Professor:
Hiroaki SHIMIZU, M.D. & Ph.D.

Lecturer:
Masataka TAKAHASHI, M.D. & Ph.D.

Assistant Professors:
Yusuke TAKAHASHI, M.D. & Ph.D.
Takahiro ONO, M.D. & Ph.D.
Syuntaro TOGASHI, M.D. & Ph.D.

Research Areas

  1. Basic research in cerebral ischemia
  2. Functional mapping and neuroimaging
  3. Computer-assisted neuronavigation surgery
  4. Intraoperative monitoring
  5. Basic research in malignant gliomas
  6. Clinical research in stereotactic irradiation
  7. Clinical research in cerebrovascular surgery
  8. Clinical research in brain tumors
  9. Clinical research in functional neurosurgery

Contact Information

Assistant Professors:
Yusuke TAKAHASHI, M.D. & Ph.D.
1-1-1 Hondo, Akita, 010-8543, Japan
Phone: +81-18-884-6140
Fax: +81-18-836-2616
E-mail: [email protected]

Most Recent Achievements

  1. 1. Hatakeyama J，Ono T，Takahashi M，Oda M，Shimizu H．（2021）Differentiating between primary central nervous system lymphoma and glioblastoma：The diagnostic value of combining 18F-Fluorodeoxyglucose positron emission tomography with arterial spin labeling．Neurol Med Chir（Tokyo）61（6）：367-375.
  2. Hata A，Oda M，Ono T，Suzuki A，Hanyu N，Takahashi M，Sasajima T，Hashimoto M，Nakase T，Shimizu H．（2021）Long-term outcomes of hypofractionated stereotactic radiotherapy for the treatment of perioptic nonfunctioning．Neurol Med Chir（Tokyo）61（7）：404-413.
  3. Asano K，Yamashita Y，Ono T，Natsumeda M，Beppu T，Matsuda K，Ichikawa M，Kanamori M，Matsuzaka M，Kurose A，Saito K，Sonoda Y，Ogasawara K，Fujii Y，Shimizu H，Ohkuma H，Kitanaka C，Kayama T，Tominaga T．（2021）The Real-World status and risk factors for a poor prognosis in elderly patients with primary central nervous system malignant lymphomas: a multicenter，retrospective cohort study of the Tohoku Brain Tumor Study Group．Int J Clin Oncol. 27（1）：77-94.
  4. Ono T，Kuwashige H，Adachi JI，Takahashi M，Oda M，Kumabe T，Shimizu H．（2021）Long-term Survival of a Patient with Diffuse Midline Glioma in the Pineal Region：A Case Report and Literature Review．Surg Neurol Int. 12：612.
  5. Matsumoto T，Ono T，Onodera T，Oda M，Takahashi M，Omae T，Shimizu H．（2021）Transventricular Preforniceal Approach Combined with Endoscopic Transnasal Surgery for a Giant Pituitary Adenoma：A Case Report and Literature Review．NMC Case Rep J．8（1）：827-833.
  6. Suda Y，Kokubun K，Takahashi Y，Saito A，Wakasa R，Shimizu H．（2020）Rapid de novo Formation of a Large Aneurysm in a Patient with Fibromuscular Dysplasia．Journal of Neuroendovascular Therapy 14（2）：69-75.
  7. Endo H, Fujimura M, Shimizu H, Endo T, Omodaka S, Inoue T, Sato K, Niizuma K, Tominaga T.（2020）Optimal Timing of Extracranial-Intracranial Bypass with Microsurgical Trapping for Ruptured Blister Aneurysms of the Internal Carotid Artery．World Neurosurg. 2020 Jan 17. pii: S1878-8750(20)30099-1. Doi：10.1016/j.wneu.2020.01.081.
  8. Takahashi Y，Suda Y，Fushimi S，Shibata K，Kondo R，Oda M，Shimizu H．（2020）Endovascular Stenting Following Stereotactic Radiosurgery for Meningioma Involving the Superior Sagittal Sinus．Journal of Neuroendovascular Therapy 14（7）：273-278，2020
  9. Ono T，Reinhardt A，Takahashi M，Nanjo H，Kamataki A，von Deimling A，Shimizu H．（2020）Comparative molecular analysis of primary and recurrent oligodendroglioma that acquired imbalanced 1p/19q codeletion and TP53 mutation：a case report．Acta Neurochir（Wien）2020 Aug 12．doi：0.1007/s00701-020-04514-3.
    Online ahead of print．https://link.springer.com/article/10.1007/s00701-020-04514-3
  10. Togashi S，Shimizu H，Suda Y．（2020）Utility of Near-infrared Spectroscopy Monitoring in the Management of Hyperperfusion Syndrome after Intracranial Carotid Artery Stenting．NMC Case Rep J 7（4）：223-227.
  11. Togashi S，Maruya J，Abe H，Nishimaki K，Ouchi H，Hara K，Tokairin T，Nishiyama K，Shimizu H．（2020）Endoscopic Management for Recurrent Hydrocephalus Associated with Neurosarcoidosis．World Neurosurgery 144：121-124.
  12. Ono T，Sasajima T，Shimizu H，Natsumeda M，Kanamori M，Asano K，Beppu T，Matsuda K，Ichikawa M，Fujii Y，Ohkuma H，Ogasawara K，Sonoda Y，Saito K，Nobusawa S，Nakazato Y，Kitanaka C，Kayama T，Tominaga T，and For the Tohoku Brain Tumor Study Group．（2020）Molecular Features and Prognostic Factors of Pleomorphic Xanthoastrocytoma：A Collaborative Investigation of the Tohoku Brain Tumor Study Group．Neurologia medico-chirurgica Advance Publication Date：October 16，2020
  13. von Deimling A，Ono T，Shirahata M，Louis DN．（2018）Grading of Diffuse Astrocytic Gliomas: A Review of Studies Before and After the Advent of IDH Testing．Semin Neurol. 2018 Feb：38（1）19-23,
  14. Shirahata M，Ono T，Stichel D，Schrimpf D，Reuss DE，Sahm F，Koelsche C，Wefers A，Reinhardt A，Huang K，Sievers P，Shimizu H，Nanjo H，Kobayashi Y，Miyake Y，Suzuki T，Adachi JI，Mishima K，Sasaki A，Nishikawa R，Bewerunge-Hudler M，Ryzhova M，Absalyamova O，Golanov A，Sinn P，Platten M，Jungk C，Winkler F，Wick A，Hänggi D，Unterberg A，Pfister SM，Jones DTW，van den Bent M，Hegi M，French P，Baumert BG，Stupp R，Gorlia T，Weller M，Capper D，Korshunov A，Herold-Mende C，Wick W，Louis DN，von Deimling A．（2018）Novel，improved grading system(s) for IDH‑mutant astrocytic gliomas．Acta.Neuropathol. 2018
  15. Stichel D，Ebrahimi A，Reuss D，Schrimpf D，Ono T，Shirahata M，Reifenberger G，Weller M，Hänggi D，Wick W，Herold-Mende C，Westphal M，Brandner S，Pfister SM，Capper D, Sahm F，von Deimling A．（2018）Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss，and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma．Acta Neuropathol. 2018 Nov：36（5）793-803.
  16. Takeshima M，Ishikawa H，Ono T，Kanbayashi T，Shimizu T．（2018）A case of perampanel-induced delirium in a patient with symptomatic epilepsy．Seizure 2018 May：58，154-155.
  17. Suzuki H，Yamaguchi S，Nishino K，Nakase T，Shimizu H．（2018）Hemodynamic ischemia of the anterior choroidal artery and reversal by carotid artery stenting 10 years after ipsilateral superficial temporal artery-middle cerebral artery bypass for symptomatic left middle cerebral artery stenosis．Neurology International 2018：10（4）
  18. Nakase T，Moroi J，Ishikawa T．（2018）Outcome of secondary stroke prevention in patients taking Non-Vitamin K antagonist oral anticoagulants．J Stroke Cerebrovasc Dis. 2018 May：27（5）1174-1177.
  19. Sasaki-Kudo E，Kudo I，Kakizaki Y，Hosaka M，Ikeda S，Uemura S，Ewa Grave，Togashi S，Sugawara T，Shimizu H，Itoh H．(2018) Cisplatin inhibit AhR activation．American Journal of Molecular Biology. 2018 Jan 18 : 69-82

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